Glaritus Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage Patient Counseling Information MIMS Class Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Insulin glargine

Indications/Uses

Treatment of type 1 or 2 DM in patients who require insulin for the control of hyperglycemia.

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Dosage/Direction for Use

SC Administer once daily at any time of the day at the same time every day. Patient w/ type 1 diabetes Approx ¹/₃ of the total daily insulin requirements. Patient w/ type 2 diabetes not currently treated w/ insulin 0.2 units/kg or up to 10 units once daily. Changing from once daily insulin glargine 300 units/mL to once daily Glaritus Initially 80% of the insulin glargine 300 units/mL dose that is being discontinued. Changing from once daily NPH insulin to once daily Glaritus Same as the dose of NPH that is being discontinued. Changing from bid NPH insulin to once daily Glaritus 80% of the total NPH dose that is being discontinued.

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Overdosage

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Contraindications

Hypersensitivity. During episodes of hypoglycemia.

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Special Precautions

Severe, life-threatening, generalized allergy, including anaphylaxis, can occur. Not intended for IV administration. Not for the treatment of diabetic ketoacidosis. Hyperglycemia or hypoglycemia w/ changes in insulin regimens. Monitor K levels in patients at risk for hypokalemia if indicated (eg, patients using K-lowering medications, or those medications sensitive to serum K conc). Concomitant use w/ PPAR-γ agonists. Hypoglycemia may impair ability to drive or operate machinery. Renal & hepatic impairment. Pregnancy & lactation. Adjust insulin doses in lactating women w/ diabetes. Childn ≤2 yr. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Na retention, edema; lipoatrophy or lipohypertrophy; transitory, reversible ophthalmologic refraction disorder, worsening of diabetic retinopathy, acute painful peripheral neuropathy; wt gain; inj site reactions including redness, pain, itching, urticaria, edema, & inflammation; severe, life-threatening, generalized allergy, including anaphylaxis, generalized skin reactions, angioedema, bronchospasm, hypotension, & shock may occur. Potential for immunogenicity. Upper resp tract infection, peripheral edema, HTN, flu, sinusitis, cataract, bronchitis, arthralgia, pain in extremity, back pain, cough, UTI, diarrhea, depression, headache, accidental injury, infection & retinal vascular disorder.

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Drug Interactions

May increase the risk of hypoglycemia w/ antidiabetic agents, ACE inhibitors, ARBs, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs (eg, octreotide) & sulfonamides. May decrease blood glucose lowering effect w/ atypical antipsychotics (eg, olanzapine & clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, INH, niacin, OCs, phenothiazines, progestogens (eg, in OCs), PIs, somatropin, sympathomimetic agents (eg, albuterol, epinephrine, terbutaline), & thyroid hormones. May increase or decrease the blood glucose lowering effect w/ alcohol, β-blockers, clonidine, & lithium salts; pentamidine. May blunt signs & symptoms of hypoglycemia w/ β-blockers, clonidine, guanethidine & reserpine.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Glaritus detailed prescribing information

Storage

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Description

View Glaritus description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Insulin Preparations

Regulatory Classification

Patient Counseling Information

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Presentation/Packing

Form

Glaritus DispoPen soln for inj 100 IU/mL

Packing/Price

3 mL x 1's

Glaritus

insulin glargine

Manufacturer:

Ambica

Distributor:

Zuellig

Marketer:

Multicare