Edema associated w/ heart failure including pulmonary edema & w/ renal & hepatic disorders; HTN. Management of oliguria due to renal failure or insufficiency.
IM/Slow IV injEdema 20-50 mg, increased by 20 mg increments not more often than 2 hrly. Doses >50 mg may be given by slow IV infusion. Pulmonary edema Initially 40 mg slow IV inj, increased to 80 mg. Childn 0.5-1.5 mg/kg daily. Max: 20 mg daily. Management of oliguria in acute or chronic renal failure where GFR is <20 mL/min 250 mg diluted to 250 mL suitable diluent infused over 1 hr. If urine output is insufficient w/in the next hr, may be followed by 500 mg infused over approx 2 hr. If not achieved w/in 1 hr at the end of 2nd infusion, 3rd dose of 1 g may be infused over approx 4 hr. Rate of infusion: Should not exceed 4 mg/min.
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