150-600 mg daily in 2 or 3 divided doses. Epilepsy Initially 150 mg daily as 2 or 3 divided doses, may be increased to 300 mg daily after 1 wk. Max: 600 mg daily after an additional wk. Generalized anxiety disorder Initially 150 mg daily, may be increased to 300 mg daily after 1 wk; may be increased to 450 mg daily after an additional wk. Max: 600 mg daily after an additional wk.
Increased risk of suicidal thoughts or behavior; worsening signs & symptoms of depression, unusual mood changes or thoughts about self-harm. Discontinue use if angioedema, hypersensitivity; myopathy is diagnosed or suspected; markedly elevated creatine kinase levels. Increased risk of accidental injury (fall) in elderly. Patients w/ history of substance abuse, underlying conditions that may precipitate encephalopathy; previous episode of angioedema & those taking other drugs associated w/ angioedema; CHF. May cause peripheral edema & wt gain; convulsions (during or shortly after treatment). Frequent assessment for those who already routinely monitored for ocular conditions & if visual disturbance persists. May affect ability to drive or operate machinery. Pregnancy & lactation. Childn <18 yr.
Potentiate effects of ethanol & lorazepam. Additive in cognitive & gross motor impairment caused by oxycodone. Reduced lower GI function w/ opioid analgesics eg, oxycodone, morphine or codeine. Increased risk of developing angioedema w/ ACE inhibitors.
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