Edema associated w/ heart failure including pulmonary edema; renal & hepatic disorders & may be effective in patients unresponsive to thiazide diuretics. HTN as monotherapy or w/ other antihypertensives. Management of oliguria due to renal failure or insufficiency.
Adult 20-80 mg single daily dose preferably in the morning, may be titrated & given in divided doses every 6-8 hr. Edema Initially 40 mg in the morning. Maintenance: 20-40 mg daily, may be increased to ≥80 mg daily in resistance edema. HTN 40-80 mg daily as monotherapy or w/ other antihypertensives. Childn Initially 2 mg/kg/dose, may be increased by 1-2 mg/kg every 6-8 hr. Max: 6 mg/kg w/ interval of at least 2 hr between doses. Edema Initially 1-3 mg/kg daily. Max: 40 mg daily. HTN Adult dose. Chronic renal impairmentOliguria Initially 250 mg, may be increased in steps of 250 mg every 4-6 hr if necessary. Max: 1.5 g in 24 hr.
Prostatic hypertrophy or impairment of micturition, impaired hearing. Not to be given in pre-comatose states associated w/ hepatic cirrhosis. 20-mg tab: Patients susceptible to FDC yellow #5 (tartrazine).
Enhanced nephrotoxicity of cephalosporins eg, cefalotin. Enhanced ototoxicity of aminoglycosides & other ototoxic drugs. Similar effects on fluids & electrolyte balance INT w/ hydrochlorothiazide. Enhanced toxicity of digitalis glycosides due to diuretic-induced hypokalemia. Increased risk or arrhythmias w/ drugs that prolong QT interval eg, astemizole, terfenadine, halofantrine, pimozide & sotalol.
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