Forosa Dosage/Direction for Use

For oral use only.
The recommended dose is one 70 mg tablet per week.
To obtain satisfactory absorption of alendronate: Alendronic acid tablets must be taken on an empty stomach immediately on rising in the morning, with plain water only, at least 30 minutes before first food, drink or other medication of the day. Other drinks (including mineral water), food and some medicines are likely to reduce this absorption of alendronate (see Interactions).
To assist delivery to the stomach and thus reduce the risk of irritation/side effects locally and in the oesophagus (see Precautions).
Alendronic acid tablets should only be swallowed on rising for the day with a whole glass of water (not less than 200 mL or 7 fl. oz).
Alendronic acid tablets should be swallowed whole. The tablets should not be chewed, sucked or allowed to dissolve in the mouth due to the risk of oropharyngeal ulceration.
Patients should not lie down until after the first meal of the day, which must be at least 30 minutes after taking the tablet.
Patients should not lie down within 30 minutes after taking Alendronic acid tablets.
Alendronic acid tablets should not be taken at bedtime or before arising for the day.
Patients should be given a calcium and vitamin D supplement if the diet is inadequate (see Precautions).
Use in elderly patients: In clinical trials, there was no age-related difference with regard to efficacy or safety profiles of alendronate. Therefore, no adjustment of the dose is necessary for elderly patients.
Use in impaired renal function: No dose adjustment is necessary in patients with a glomerular filtration rate (GFR) greater than 35 mL/min. Alendronate is not recommended for patients with impaired renal function if the GFR is less than 35 mL/min, as there is no experience of this.
Use in impaired hepatic function: No dose adjustment is necessary.
Use in children (under 18 years): Alendronate has been studied in a small number of patients with osteogenesis imperfecta under 18 years of age. Results are insufficient to support its use in children. Alendronic acid 70 mg has been investigated in the treatment of glucocorticoid-induced osteoporosis.