Each tablet contains Folic acid 5 mg.
Pharmacotherapeutic Group: Antianemic agent.
Pharmacology: Pharmacokinetics: It is rapidly absorbed from the gastrointestinal tract, mainly from the duodenum and jejunum. Dietary folates are stated to have about half the bioavailability of crystalline folic acid. Naturally occurring folate polyglutamates are largely deconjugated and reduced by dihydrofolate reductase in the intestines to form 5-methyltetrahydrofolate which appears in the portal circulation, where it is extensively bound to plasma proteins. Folic Acid administered therapeutically enters the portal circulation largely unchanged since it is poor substrate for reduction by dihydrofolate reductase. It is converted to the metabolically active form 5-methyltetrahydrofolate in the plasma and liver. Folate undergoes enterohepatic circulation. Folate metabolites are eliminated in the urine and folate in excess of body requirements is excreted unchanged in the urine. Folate is distributed into the breast milk. Folic acid is removed by haemodialysis.
For the treatment and prevention of folate deficiency. It is also used in women of child-bearing potential and pregnant women to protect against neural tube defects in their offspring.
Treatment of folate-deficient megaloblastic anaemia: 5 mg or 1 tablet daily for 4 months; up to 15 mg or 3 tablets daily in malabsorption states. Continued administration of 5 mg folic acid every 1 to 7 days may be necessary in chronic haemolytic states depending on the diet and rate of haemolysis.
Prevention of neural tube defects in the offspring of pregnant women of child-bearing potential: 5 mg or 1 tablet daily starting before pregnancy and continued through the first trimester or as prescribed by the physician.
Folic acid should never be given alone or in conjunction with inadequate amounts of Vitamin B12 for the treatment of undiagnosed megaloblastic anaemia, since folic acid may produce a haematopoietic response in patients with megaloblastic anaemia due to Vitamin B12 deficiency without preventing aggravation of neurological symptoms.
Folic Acid is generally well tolerated. Gastrointestinal disturbances and hypersensitivity reactions have been reported rarely.
Folate deficiency states that may be produced by a number of drugs including antiepileptics, oral contraceptives, antituberculous drugs, alcohol, and folic acid antagonists such as aminopterin, methotrexate, pyrimethamine, trimethoprim, and sulfonamides.
B03BB01 - folic acid ; Belongs to the class of folic acid and derivatives. Used in the treatment of anemia.
Foladin tab 5 mg
100's (P950/box, P9.5/tab)
Sign Out
