Adult Cryptococcal meningitis & infections at other sites 400 mg on the 1st day followed by 200-400 mg once daily. At least 6-8 wk for cryptococcal meningitis.
Prevention of relapse of cryptococcal meningitis in patient w/ AIDS, after receiving a full course of primary therapy Indefinitely at 200 mg daily.
Candidemia, disseminated candidiasis & other invasive candidal infections 400 mg on the 1st day followed by 200 mg daily, may be increased to 400 mg daily.
Oropharyngeal candidiasis 50-100 mg once daily for 7-14 days. If necessary, can be continued for longer periods in patient w/ severely compromised immune function.
Atrophic oral candidiasis associated w/ dentures 50 mg once daily for 14 days w/ local antiseptic measures to the denture.
Other candidal infections of mucosa except genital candidiasis (eg, esophagitis, non-invasive bronchopulmonary infections, candiduria, mucocutaneous candidiasis) 50-100 mg daily for 14-30 days.
Prevention of relapse of oropharyngeal candidiasis in patient w/ AIDS, after receiving a full course of primary therapy 150 mg once wkly.
Vag candidiasis & candida balanitis 150 mg as a single dose.
Recurrent vag candidiasis 150 mg once mthly. Duration: 4-12 mth.
Prevention of candidiasis 50-400 mg once daily.
Dermal infections including tinea pedis, corporis, cruris & candida 150 mg once wkly or 50 mg once daily. Duration: 2-4 wk but tinea pedis may require up to 6 wk.
Tinea versicolor 300 mg once wkly for 2 wk; 3rd wkly dose of 300 mg may be needed, whereas, single dose of 300-400 mg may be sufficient. Alternate dosing: 50 mg once daily for 2-4 wk.
Tinea unguium 150 mg once wkly.
Deep endemic mycoses 200-400 mg daily for up to 2 yr. Duration: 11-24 mth w/ coccidioidomycosis, 2-7 mth w/ paracoccidioidomycosis, 1-16 mth w/ sporotrichosis & 3-17 mth w/ histoplasmosis.
Childn Mucosal candidiasis 3 mg/kg daily. Loading dose: 6 mg/kg on the 1st day to achieve steady state levels more rapidly.
Systemic candidiasis & cryptococcal infections 6-12 mg/kg daily.
Suppression of relapse of cryptococcal meningitis in childn w/ AIDS 6 mg/kg once daily.
Prevention of fungal infections in immunocompromised patient 3-12 mg/kg daily.
Neonate <4 wk Same dosing w/ older childn in the 1st 2 wk every 72 hr. During wk 3-4, same dose should be given every 48 hr.
Renal impairment Initially 50-400 mg loading dose.
Sign Out
