Adult Single agent: 15 mg/kg (max: 1 g) IV infusion daily, diluted in 300 to 500 mL of glucose 5% given over a period of 4 hr.
WBC count has risen to 3,000-4,000/mm3 or platelet count to 80,000-100,000/mm3 Maintenance: 12 mg/kg daily IV inj for 3 consecutive days. If toxic effects do not appear, patient may be given 6 mg/kg IV on the 5th, 7th & 9th days. If there are still no signs of toxicity, the patient may be placed on maintenance therapy of 5-10 mg/kg by IV inj once a wk. In combination w/ other cytostatic agents or w/ radiotherapy: 5-7 mg/kg daily as a 24-hr intra-arterial continuous drip infusion. Suggested regimens w/ folinic acid include: 200 mg/m
2 of folinic acid (as Ca folinate) by slow IV inj followed immediately by an IV bolus of fluorouracil 370 mg/m
2 for 5 consecutive days & may be repeated every 4-5 wk. The Mayo regimen: Lower doses of folinic acid (20 mg/m
2) followed by fluorouracil 425 mg/m
2 for 5 consecutive days, repeated every 4-5 wk. The de Gramont regimen: Initial dose of 200 mg/m
2 of folinic acid, followed by fluorouracil 400 mg/m
2 as an initial IV bolus inj & then 600 mg/m
2 by continuous IV infusion given for 2 consecutive days every 2 wk.
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