OA 200 mg/day as single or 2 divided doses. RA 100-200 mg bid. Pain & dysmenorrhea Initially 400 mg followed by additional dose of 200 mg if necessary on the 1st day then 200 mg bid thereafter. FAP 400 mg bid.
May be taken with or without food: Dose for OA/RA may be given w/ or w/o meals, but doses for familial adenomatous polyposis must be given w/ meals.
Contraindications
Severe heart failure, inflammatory bowel disease, asthma, urticaria. Patients who have a history of stroke, CVA, heart attack, MI, CABG, uncontrolled HTN, CHF, NYHA II-IV. Renal impairment (CrCl <30 mL/min).
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