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Tablet: Amebiasis: The duration of treatment is 7 consecutive days.
Adults: 1.50 g daily, in 3 divided doses.
Children: 30 to 40 mg/kg/day, in 3 divided doses.
In hepatic amebiasis, at the abscess stage, the abscess must be evacuated concomitantly with metronidazole treatment.
Giardiasis: The duration of treatment is 5 consecutive days.
Adults: 0.750 to 1 g daily.
Children: From 2 to 5 years: 250 mg/day.
From 5 to 10 years: 375 mg/day.
From 10 to 15 years: 500 mg/day.
Trichomoniasis: In women (urethritis and vaginitis due to Trichomonas): single dose of 2 g or 500 mg/day by oral route in two divided doses for 10 days.
Whether or not the partner presents clinical signs of infection with Trichomonas vaginalis, he must be treated concurrently, even in the absence of positive laboratory tests.
In men (urethritis due to Trichomonas): 2 g in a single dose or 500 mg by oral route in 2 divided doses for 10 days.
Non-specific vaginitis: 500 mg, twice daily for 7 days.
The partner must be treated simultaneously.
Treatment of anaerobic infections: As first line treatment or substitute treatment: Adults: 1 to 1.5 g/day.
Children: 20 to 30 mg/kg/day.
Surgical chemoprophylaxis: The studies published in the literature do not make it possible to define the ideal protocol for surgical chemoprophylaxis Metronidazole must be combined with a product active against Enterobacteria.
One 500 mg dose every 8 hours, the treatment being begun approximately 48 hours before surgery, appears to be effective.
The last dose must be administered at the latest 12 hours before surgery.
The goal of chemoprophylaxis is to reduce the bacterial inoculum in the gastro-intestinal tract at the time of surgery; it is therefore useless to continue the antibiotic in the post-operative period, at least by the oral route.
Children: same protocol at a dosage of 20 mg to 30 mg/kg/day.
Oral Suspension: Trichomoniasis: Adults: Given orally either as a single 2 g dose, as a 2-day course of 800 mg in the morning and 1.2 g in the evening, or as a 7-day course of 600 mg to 1 g daily in two or three divided doses.
Anaerobic infections: Given orally in an initial dose of 800 mg followed by 400 mg every 8 hours, usually for about 7 days.
Amoebiasis: Adults: Given in oral doses of 400 to 800 mg three times daily for 5 days to 10 days. An alternative adult dose is 1.5 to 2.5 g as a single daily dose for 2 or 3 days.
Children: Aged 1 to 3 years may be given one-quarter, those aged 3 to 7 years one-third, and those aged 7 to 10 years one-half the total adult daily dose, alternatively 35 to 50 mg/kg daily in divided doses.
Giardiasis: Adults: Usually oral dose is 2 g once daily for 3 successive days, or 400 mg three times daily for 5 days, or 500 mg twice daily for 7 to 10 days.
Children: Alternative schedule for children is 15 mg/kg daily in divided doses. Or as prescribed by the physician.
