Adult 1 tab bid-tid. May decrease to ½ tab bid based on prescription on elderly or w/ concomitant CV, hepatic, renal or gastric disease. Childn 12 mg/kg daily, divided into 2 doses. Can be increased up to 18 mg/kg daily.
Do not administer w/ other xanthine derivatives. Toxic synergism w/ ephedrine. May decrease hepatic clearance w/ erythromycin, troleandomycin, lincomycin, clindamycin, allopurinol, cimetidine, ranitidine, propranolol & anti-flu vaccine. May increase in clearance w/ shorter mean t½ w/ phenytoin, other anti-convulsants & smoking.
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