Febustin Dosage/Direction for Use

The recommended oral dose of Febuxostat is 40 mg or 80 mg once daily without regard to food. The recommended starting dose of Febuxostat is 40 mg once daily. If serum uric acid is > 6 mg/dL (357 μmol/L) after 2-4 weeks, Febuxostat 80 mg once daily is recommended. Febuxostat works sufficiently quickly to allow retesting of the serum uric acid after 2 weeks. The therapeutic target is to decrease and maintain serum uric acid below 6.0 mg/dL (357 μmol/L). Gout flare prophylaxis of at least 6 months is recommended. No dose adjustment is required in the elderly.
Renal & Hepatic Impairment: The efficacy and safety have not been fully evaluated in patients with severe renal impairment and severe hepatic impairment. No dose adjustment is necessary in patients with mild or moderate renal impairment and mild hepatic impairment. Limited information is available in patients with moderate hepatic impairment.
Pediatric population: Safety and the efficacy of Febuxostat in children aged below the age of 18 years have not been established. No data are available.