Not recommended in patients w/ ischaemic heart disease or CHF; patients in whom the rate of urate formation is greatly increased (eg, malignant disease & its treatment, Lesch-Nyhan syndrome); organ transplant recipients. Stop treatment immediately if serious allergic/hypersensitivity reactions including Stevens-Johnson syndrome & acute anaphylactic reaction/shock occur. Do not start treatment until an acute attack of gout has completely subsided; flare prophylaxis for at least 6 mth w/ an NSAID or colchicine is recommended. Concomitant treatment w/ mercaptopurine/azathioprine. Liver function test is recommended prior to the initiation of therapy & periodically thereafter. Patients w/ alteration of thyroid function. Contains lactose; rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. May affect ability to drive & use machines. Severe renal impairment (CrCl <30 mL/min). Moderate to severe hepatic impairment. Not to be used during pregnancy & lactation. Childn <18 yr.
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