Discontinue use & initiate appropriate therapy if an anaphylactic or other clinically significant allergic reactions occur. Not to be initiated in patients who had MI or stroke w/in the preceding yr. Discontinue use if patient experiences MI or stroke during therapy. Correct hypocalcaemia prior to initiating therapy. Monitor patients for signs & symptoms of hypocalcemia. Patients should be adequately supplemented w/ Ca & vit D. Risk of osteonecrosis of the jaw generally associated w/ tooth extraction &/or local infection w/ delayed healing; atypical low-energy or trauma fracture of femoral shaft. Greater risk of developing hypocalcemia in patients w/ severe renal impairment (eGFR 15-29 mL/min/1.73 m
2) or those receiving dialysis. Pregnancy & lactation. Not to be used in paed patients.
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