View Episopt overdosage for action to be taken in the event of an overdose.
Contraindications
Hypersensitivity. Reactive airway disease, including bronchial asthma or history of bronchial asthma, or severe COPD. Sinus bradycardia, sick sinus syndrome SA block, 2nd- or 3rd-degree AV block not controlled w/ pace-maker, overt cardiac failure, cardiogenic shock. Severe renal impairment (CrCl <30 mL/min) or hyperchloraemic acidosis.
Patients w/ history of atopy or severe anaphylactic reaction to a variety of allergens. Patients w/ CV diseases (eg, CHD, Prinzmetal's angina & cardiac failure) & hypotension therapy w/ β-blockers; 1st degree heart block. Severe peripheral circulatory disturbance/disorders (eg, severe forms of Raynaud's disease/syndrome). Mild/moderate COPD. May mask the signs & symptoms of acute hypoglycemia & hyperthyroidism in patients subjected to spontaneous hypoglycemia or w/ labile diabetes. Patients w/ corneal diseases; may induce dryness of eyes. Choroidal detachment may occur after filtration procedures. Blocks systemic β-agonist effects eg, adrenaline. Discontinue if serious reactions or hypersensitivity occurs. Concomitant use w/ carbonic anhydrase inhibitors; other β-blocking agents is not recommended. W/drawal of therapy in patients w/ CHD should be gradual. May aggravate symptoms of myasthenia gravis. Increased risk of urolithiasis in patients w/ prior history of renal calculi. Patients w/ acute angle closure glaucoma; patients w/ pre-existing chronic corneal defects &/or history of intra-ocular surgery. May discolor soft contact lenses. May affect the ability to drive & use machine. Hepatic impairment. Pregnancy. Do not use during lactation. Childn <2 yr.
Concomitant use w/ adrenaline (epinephrine) may cause mydriasis. May increase hypoglycemic effect of antidiabetic agents. Oral β-adrenergic blocking agents may exacerbate the rebound HTN following the w/drawal of clonidine. Timolol: May potentiate systemic β-blockade w/ CYP2D6 inhibitors (eg, quinidine, fluoxetine, paroxetine); Concomitant use w/ oral Ca channel blockers, β-adrenergic blocking agents, antiarrhythmics (including amiodarone), digitalis glycosides parasympathomimetic, guanethidine may cause additive effects resulting in hypotension &/or marked bradycardia.
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