Adult Epilepsy 25 mg once daily for 1 wk, increased thereafter by increments of 25-50 mg at 1-2 wk intervals. Daily dose >25 mg should be taken in 2 divided doses. Adjunctive therapy: 200-400 mg, up to 800 mg daily. Monotherapy: 100-400 mg daily.
Migraine 25 mg/day for 1st wk, & increased thereafter by increments of 25 mg. Dosage >25 mg should be taken in 2 divided doses. Usual dose: 100 mg.
Childn 2-16 yr Epilepsy Adjunctive therapy:
25 mg nightly for the 1st wk, increased by increments of 1-3 mg/kg/day at 1-2 wk interval. Recommended dose: 5-9 mg/kg/day given in 2 doses, up to 30 mg/kg/day. Monotherapy:
Childn ≥6 yr Initially 0.5-1 mg/kg at night for the 1st wk, increased by increments of 0.5-1 mg/kg/day at 1-2 wk intervals. Usual dose: 3-6 mg/kg/day in 2 divided doses.
Patient w/ renal impairment: CrCl <70 mL/min/1.73 m2 ½ of adult dose.
Patient undergoing hemodialysis ½ of daily dose in divided doses at the start & finish of the procedure.
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