Adult 2 cap or 200 mg on 1st day in single or divided doses of 1 cap every 12 hr; then 1 cap daily thereafter. Severe infections 1 cap every 12 hr. Acute gonococcal infections 200 mg at once & 100 mg at bedtime on 1st day, followed by 100 mg bid for 3 days. Administer 300 mg at once followed in 1 hr by 2nd 300-mg dose as alternative single visit dose. Primary & secondary syphilis 300 mg daily in divided doses for at least 10 days; continue treatment even after the time that symptoms & fever have subsided. Streptococcal infections Continue therapy for 10 days to prevent rheumatic fever or glomerulonephritis development.
View Dynadoxy overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food: Take w/ a full glass of water & remain upright for at least 30 min. Take w/ food or milk if GI irritation occurs.
Contraindications
Hypersensitivity. Enamel hypoplasia. Use in tooth development during last ½ of pregnancy, infancy & childhood 8 yr may cause permanent teeth discoloration (yellow-gray-brown).
Avoid w/ penicillin. Treat all infections due to group A β-hemolytic strep for at least 10 days. Patients on anticoagulant therapy may require downward adjustment of their anticoagulant dosage, due to depressed plasma prothrombin activity. Photosensitivity; discontinue treatment at 1st evidence of skin erythema. May result in overgrowth of non-susceptible organisms including fungi. Superinfection. Dark field exam should be done before treatment is started & blood serology repeated mthly for at least 4 mth in venereal diseases when coexistent w/ syphilis is suspected. False elevations of urinary catecholamine levels w/ fluorescence test. Perform periodic lab evaluation of organ systems, including hematopoietic, renal & hepatic studies in long term therapy. May cause an increase in BUN. Decrease in fibula growth rate in prematures. Pregnancy & lactation. Childn <8 yr.
Impaired absorption w/ antacids containing Al, Ca, or Mg, Zn, Fe-containing prep & bismuth subsalicylate. Prolongation of prothrombin time w/ anticoagulants. May interfere w/ bactericidal action of penicillin & aminoglycosides. Serum t½ may be decreased w/ barbiturates, carbamazepine, phenytoin & other hepatic enzyme inducers. May decrease efficacy of contraceptives.
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