Duomax Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Rifampicin 150 mg, INH 75 mg

Indications/Uses

For the continuation phase of short-course treatment of patients w/ pulmonary & extra-pulmonary TB.

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Dosage/Direction for Use

Adult weighing >70 kg 5 tab/day; 55-70 kg 4 tab/day; 38-54 kg 3 tab/day; 30-37 kg 2 tab/day. Duration: 4 mth.

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Overdosage

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Administration

Should be taken on an empty stomach: Take at least 30 min before or 2 hr after meals.

Contraindications

Hypersensitivity. Severe hepatic damage, acute liver disease & acute gout.

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Special Precautions

Patients w/ DM. May produce a reddish coloration of the urine, sweat, sputum & tears.

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Adverse Reactions

Epigastric distress, anorexia, nausea, vomiting, jaundice. Rifampicin: Heartburn, flatulence, cramps & diarrhea. Thrombocytopenia, transient leukopenia, hemolytic anemia, decreased Hb, headache, fever, drowsiness, fatigue, ataxia, dizziness, mental confusion, behavioral changes, visual disturbances, elevations in BUN & serum uric acid, flushing & itching w/ or w/o rash, pruritus, urticaria, pemphigoid reaction, eosinophilia & conjunctivitis. INH: Severe agranulocytosis, hemolytic, sideroblastic or aplastic anemia, thrombocytopenia & eosinophilia, pyridoxine deficiency, pellagra, hyperglycemia, metabolic acidosis, gynecomastia, rheumatic syndrome & systemic lupus erythematosus.

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Drug Interactions

Rifampicin: Phenytoin, antiarrhythmics, anticoagulants, antifungals, barbiturates, β-blockers, Ca-channel blockers, chloramphenicol, ciprofloxacin, corticosteroids, cyclosporine, cardiac glycoside, OCs, clofibrate, dapsone, diazepam. INH: Anticonvulsants, benzodiazepines, haloperidol, ketoconazole, theophylline & warfarin.

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Storage

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Description

View Duomax description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Anti-TB Agents

ATC Classification

J04AM02 - rifampicin and isoniazid ; Belongs to the class of combination drugs used in the systemic treatment of tuberculosis.

Regulatory Classification

Presentation/Packing

Form

Duomax FC tab

Packing/Price

80's

Duomax

rifampicin + isoniazid

Manufacturer:

Multicare

Distributor:

Zuellig