AdultUncomplicated UTI eg, cystitis 1-2 g daily, given as single dose or 2 equally divided doses. Other UTI 2 g daily or 2 equally divided doses. Skin structure infections 1 g daily given as a single dose or in 2 equally divided doses. Group A β-hemolytic Strep pharyngitis & tonsillitis 1 g daily as a single dose or in 2 equally divided doses for at least 10 days. Resp infections 500 mg bid. Moderate-severe infections 500-1000 mg every 12 hr. ChildnUTI & skin infections 30 mg/kg/day in divided doses every 12 hr. Pharyngitis & tonsillitis 30 mg/kg/day in single dose or in 2 divided doses. Group A β-hemolytic Strep infections Duration: At least 10 days.
Possibility of cross-allergy w/ penicillin-allergic patients. Impaired renal function (CrCl <50 mL/min/1.73 m2) & colitis. Prolonged use may result in overgrowth of nonsusceptible organisms. Pregnancy & lactation.
Probenecid increases serum conc. Aminoglycosides, colistin, polymyxin B or vancomycin may increase risk of nephrotoxicity. Additive or synergistic w/ aminoglycosides or penicillins.
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