Given by IV infusion in glucose 5% or NaCl 0.9% at conc not >0.74 mg/mL over 1 hr. Premedication: Dexamethasone 16 mg daily for 3 days starting 1 day before taking Docetaxel.
Locally advanced or metastatic breast cancer As single agent: 100 mg/m
2; in combination w/ doxorubicin: 75 mg/m
2; in combination w/ trastuzumab: 100 mg/m
2 every 3 wk, w/ trastuzumab administered wkly; in combination w/ capecitabine: 75 mg/m
2 every 3 wk combined w/ capecitabine at 1,250 mg/m
2 bid (w/in 30 min after a meal) for 2 wk followed by a wk rest period.
NSCLC 75 mg/m
2 once every 3 wk, for both 1st-line combination therapy & monotherapy after failure of previous chemotherapy.
Gastric adenocarcinoma 75 mg/m
2 given before cisplatin & fluorouracil, repeated every 3 wk.
Induction treatment of head & neck cancer 75 mg/m
2 given before cisplatin & fluorouracil every 3 wk for 3 cycles, followed by chemoradiotherapy or for 4 cycles when followed by radiotherapy alone.
Prostate cancer 75 mg/m
2 once every 3 wk w/ prednisone or prednisolone 5 mg orally bid given continuously.
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