IV inj Given slowly at a rate of approx 1 mg in 30 sec.
Conscious sedation Adult <60 yr Initially 2.5 mg given 5-10 min before the beginning of the procedure. Further doses of 1 mg may be given as necessary.
Adult >60 yr, debilitated or chronically ill patient Reduce initial dose to 1-1.5 mg & given 5-10 min before the beginning of the procedure. Further doses of 0.5-1 mg may be given as necessary.
IV induction Each increment of not >5 mg should be inj over 20-30 sec allowing 2 min between successive increments.
Premedicated adult <60 yr 0.15-0.2 mg/kg.
Non-premedicated adult <60 yr 0.3-0.35 mg/kg.
Adult >60 yr, debilitated or chronically ill patient Lower doses will be required.
Maintenance 0.03-0.1 mg/kg/hr by either further intermittent doses or continuous IV infusion in combination w/ narcotics or ketamine.
IV loading dose Each increment of 1-2.5 mg should be inj over 20-30 sec allowing 2 min between successive increments.
Sedation in the ICU Loading dose: 0.03-0.3 mg/kg. Maintenance dose: 0.03-0.2 mg/kg/hr.
Hypovolemic, vasoconstricted or hypothermic patient Loading dose: Reduce or omit dose. Maintenance dose: Reduce dose, at times to as low as 25% of the usual dose.
IM Premed before induction of anesth Adult <60 yr 0.07-0.1 mg/kg according to the general condition of the patient. Usual dose: 5 mg.
Adult >60 yr, debilitated or chronically ill patient 0.025-0.05 mg/kg. Usual dose: 2-3 mg.
Childn 1-15 yr 0.08-0.2 mg/kg.
Childn receiving ketamine for anesth (ataralgesia) 0.15-0.2 mg/kg.
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