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Pharmacology: Pharmacokinetics: Furosemide is fairly rapidly absorbed from the gastrointestinal tract; bioavailability has been reported to be about 60 to 70% but absorption is variable and erratic. The half-life is up to about 2 hours, it is prolonged in neonates and in patients with renal and hepatic impairment. It is up to 99% bound to plasma albumin, and is mainly excreted in the urine, largely unchanged. Furosemide crosses the placenta barrier and is distributed into breastmilk. The clearance of Furosemide is not increased by hemodialysis.
Potassium salts are generally readily absorbed from the gastrointestinal tract. Potassium is excreted mainly from the kidneys; it is secreted in their distal tubules in exchange for sodium or hydrogen ions. Some potassium is excreted in the feces and small amounts may also be excreted in sweat.
