Adult HTN 80 or 160 mg once daily. May be increased to 320 mg once daily or add another antihypertensive (eg, diuretic) if BP reduction is inadequate.
Heart failure Initially 40 mg bid, up-titrated to 80 & 160 mg bid as tolerated. Max: 320 mg daily in divided doses.
Post-MI Initially 20 mg bid, up-titrated to a max of 160 mg bid as tolerated.
Hypertensive patient w/ IGT at CV risk Progression of type 2 diabetes 80 or 160 mg once daily. When started on 80 mg, up-titrate to 160 mg as tolerated.
Childn & adolescent 6-18 yr HTN Initially 40 mg (<35 kg) or 80 mg (≥35 kg) once daily.