Adult Cryptococcal meningitis & cryptococcal infections at other sites 400 mg on the 1st day followed by 200-400 mg once daily. Administer at least 6-8 wk for cryptococcal meningitis.
Prevention of relapse of cryptococcal meningitis in patient w/ AIDS after a full course of primary therapy Administer indefinitely at 200 mg once daily.
Candidemia, disseminated candidiasis & other invasive candidal infections 400 mg on the 1st day followed by 200 mg once daily, may be increased to 400 mg once daily.
Oropharyngeal candidiasis 50-100 mg once daily for 7-14 days. Can be continued for longer periods in patient w/ severely compromised immune function.
Atrophic oral candidiasis associated w/ dentures 50 mg once daily for 14 days concurrently w/ local antiseptic measures to the denture.
Other candidal infections of mucosa except genital candidiasis (eg, esophagitis, non-invasive bronchopulmonary infections, candiduria, mucocutaneous candidiasis) 50-100 mg once daily for 14-30 days.
Prevention of relapse of oropharyngeal candidiasis in patient w/ AIDS after a full course of primary therapy 150 mg once wkly.
Vag candidiasis & candida balanitis 150 mg as single oral dose.
Recurrent vag candidiasis incidence reduction 150 mg once mthly for 4-12 mth.
Prevention of candidiasis 50-400 mg once daily.
Patient at high risk of systemic infection eg, patient w/ anticipated profound or prolonged neutropenia 400 mg once daily, starting several days before the anticipated onset of neutropenia & continue for 7 days after the neutrophil count rise >1,000 cell/mm
3.
Dermal infections including tinea pedis, tinea corporis, tinea cruris & candida infections 150 mg once wkly or 50 mg once daily. Duration of treatment: 2-4 wk, but tinea pedis may require for up to 6 wk.
Tinea versicolor 300 mg once wkly for 2 wk. 3rd wkly dose of 300 mg may be needed in some patient, whereas, a single dose of 300-400 mg may be sufficient. Alternate dosing regimen: 50 mg once daily for 2-4 wk.
Tinea unguium 150 mg once wkly, continued until infected nail is replaced (uninfected nail grows in).
Deep endemic mycoses 200-400 mg once daily for up to 2 yr. Duration of therapy: Coccidioidomycosis 11-24 mth; paracoccidioidomycosis 2-17 mth; sporotrichosis 1-16 mth; histoplasmosis 3-17 mth.
Childn Mucosal candidiasis 3 mg/kg once daily. Loading dose: 6 mg/kg on the 1st day.
Systemic candidiasis & cryptococcal infections 6-12 mg/kg once daily.
Suppression of relapse of cryptococcal meningitis in childn w/ AIDS 6 mg/kg once daily.
Prevention of fungal infections in immunocompromised patient considered at risk as a consequence of neutropenia following cytotoxic chemotherapy or RT 3-12 mg/kg once daily.
Neonate ≤4 wk 1st 2 wk of life: Same dose w/ older childn administered every 72 hr. Wk 3 & 4 of life: Same dose should be given every 48 hr.
Renal impairment in adult & childn Initial loading dose: 50-400 mg.
CrCl >50 mL/min 100% recommended dose;
≤50 mL/min (no dialysis) 50% recommended dose.
Hemodialysis 100% recommended dose after each hemodialysis. Reduce dose according to the patient's CrCl on non-dialysis days.
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