Treatment of susceptible infections including pneumonia, nosocomial pneumonia, UTI; intra-abdominal, gynecological (eg, endometritis), skin & skin structure, bone & joint infections; meningitis, septicemia, endocarditis in adults & childn. Monotherapy or in combination w/ antiviral or antifungal agents in the empiric treatment for suspected infection in adults w/ febrile neutropenia.
AdultPneumonia, UTI, gynecological infections eg, endometritis, skin & skin structure infections 500 mg. Nosocomial pneumonia, peritonitis, presumed infections in neutropenic patients, septicemia 1 g. Meningitis 2 g. Childn >50 kg Adult dosage, >3 mth-12 yr 10-20 mg/kg. Meningitis 40 mg/kg. Doses are administered 8 hrly given as IV bolus inj over 5 min or IV infusion over 15-30 min. Renal impairment CrCl 26-50 mL min Full recommended dose (500 mg, 1 g or 2 g) every 12 hr, 10-25 mL/min ½ recommended dose (250 mg, 500 mg or 1 g) every 12 hr, <10 mL/min ½ recommended dose (250 mg, 500 mg or 1 g) every 24 hr.
History of hypersensitivity to penicillins or other β-lactams. Methicillin-resistant staphylococci infections. May result in overgrowth of nonsusceptible organisms. Careful monitoring of transaminase & bilirubin levels in patients w/ hepatic disease. History of GI complaints particularly colitis. Consider diagnosis of pseudomembranous colitis in patients who develop diarrhea. Co-administration w/ potentially nephrotoxic drugs. CNS disorders or bacterial meningitis &/or compromised renal function. Pregnancy & lactation. Infant <3 mth.
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