Chronic Fe overload Adult & childn 20-60 mg/kg daily.
Patient w/ higher serum ferritin May require up to 55 mg/kg daily,
serum ferritin level between 2,000 & 3,000 ng/mL 35 mg/kg daily,
serum ferritin level <2,000 ng/mL 25 mg/kg daily.
Acute Fe poisoning 15 mg/kg/hr by continuous IV, reduced as soon as circumstances permit, usually after 4-6 hr, so that total IV dose does not exceed 80 mg/kg in any 24-hr period.
Chronic Al overload in end-stage renal failure 5 mg/kg once wkly administered by slow IV infusion 5 hr prior to dialysis session in patient w/ post-DFO test serum Al level >300 ng/mL or during the last 60 min of dialysis session in patient w/ post-DFO test serum Al level up to 300 ng/mL. After completion of the 1st 3-mth course of treatment followed by a 4-wk wash-out period, infusion test should be performed. If 2 successive infusion tests performed at 1-mth interval yield serum Al level <50 ng/mL above baseline, further treatment is not recommended.
Patient on continuous ambulatory peritoneal dialysis or continuous cyclic peritoneal dialysis 5 mg/kg once wkly prior to the final exchange of the day given IP, IM, by slow IV infusion or SC.
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