Dazomet

Metronidazole

Infections caused by susceptible anaerobic microorganisms; peri-op prophylaxis to reduce incidence of post-op bacterial infections in patients at high risk for such infections. Intestinal & extraintestinal or invasive amoebiasis including amoebic liver abscess. Pelvic inflammatory disease (PID) in combination w/ fluoroquinolones.

Tab Adult Trichomoniasis 2 g as a single dose or 500 mg bid for 7 days. Giardiasis 250 mg tid for 5-7 days. Amoebiasis 500-750 mg tid for 7-10 days. Vag infections including bacterial vaginosis 2 g as single dose or 500 mg bid for 7 days. Partner should be treated simultaneously. Anaerobic infections as 1st-line or substitute treatment 1-2 g/day every 6-12 hr or 500 mg every 6 hr in 2-4 divided doses. Slow IV infusion Administer over 30-60 min. Treatment of infections caused by susceptible microorganisms Adult 500 mg every 6-8 hr. Childn 20-30 mg/kg/day in 3-4 divided doses every 6-8 hr. Max: 4 g daily. Periop prophylaxis against anaerobic infections Adult 500 mg shortly before the procedure & 500 mg after 8 & 16 hr. Childn 7.5 mg/kg as single dose shortly before the procedure. Administer 2nd dose of 7.5 mg/kg when surgery is delayed/prolonged. Intestinal & hepatic amoebiasis Adult 500 mg every 8 hr. Childn 30-40 mg/kg/day every 8 hr. PID 500 mg every 8 hr.

Should be taken with food.

Patients w/ history of blood dyscrasias; receiving corticosteroids & those predisposed to edema. Candida overgrowth in GI or genital tract may occur. Perform total & differential leukocyte counts before & after treatment. Severe hepatic disease. Avoid alcoholic intake during therapy & for at least 3 days afterward.

Convulsive seizures & peripheral neuropathy; numbness or paresthesia of an extremity; dizziness, vertigo, incoordination, ataxia, confusion, irritability, depression, weakness, headache, tinnitus, hearing loss, insomnia; nervousness, malaise or syncope; nausea, headache, anorexia, dry mouth & sharp, unpleasant metallic taste, vomiting, abdominal discomfort, diarrhea, epigastric distress & constipation; reversible neutropenia (leukopenia); flattening of T-wave; urticaria, pruritus, maculopapular rash, erythematous rash, flushing, nasal congestion, dryness of mouth (or vag or vulva), fever & fleeting joint pains; dysuria, cystitis, polyuria, incontinence, sense of pelvic pressure; urethral burning or discomfort, dryness of the vag, proliferation of vag candida, dyspareunia, decreased libido, proctitis; genital pruritus, dysmenorrhea, UTI; darkened urine; upper resp tract infections, rhinitis, sinusitis & pharyngitis; thrombophlebitis.

Antiamoebics / Other Antibiotics

J01XD01 - metronidazole ; Belongs to the class of imidazole derivative antibacterials. Used in the systemic treatment of infections.
P01AB01 - metronidazole ; Belongs to the class of nitroimidazole derivatives antiprotozoals. Used in the treatment amoebiasis and other protozoal diseases.

Rx