Daphne Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing Brand Resources

Concise Prescribing Info

Contents

Lynestrenol

Indications/Uses

Contraception, notably in cases of intolerance to estrogen-progestogen combined pills or when estrogens are contraindicated. Lactating mothers & smoking women who require contraception.

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Dosage/Direction for Use

1 tab daily beginning on the 1st day of menstrual bleeding, interval between 2 tab should be 24 hr. Start a new pack the next day after taking the last tab. If a tab is missed for <3 hr, take immediately. Resume taking the next tab.

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Overdosage

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Administration

May be taken with or without food: May be taken w/ meals to reduce GI discomfort.

Contraindications

Porphyria, severe arterial disease, undiagnosed vag bleeding, hormone-dependent neoplasms, severe liver disease eg, hepatic adenoma, after recent evacuation of hydatidiform mole. Pregnancy.

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Special Precautions

Asthma, DM, epilepsy, heart disease, HTN, thromboembolic disorders, history of depression, past ectopic pregnancy, functional ovarian cysts, malabsorption syndromes, migraine, other conditions which may be aggravated by fluid retention. Renal impairment. Liver dysfunction including cholestatic jaundice or history of jaundice in pregnancy.

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Adverse Reactions

GI disturbances, changes in appetite or wt, fluid retention, edema, chloasma, allergic skin rashes, urticaria, mental depression, breast changes including discomfort or occasionally gynecomastia, changes in libido, hair loss, hirsutism, fatigue, drowsiness, insomnia, fever, headache, premenstrual syndrome-like symptoms & altered menstrual cycles or irregular menstrual bleeding, alterations in the serum lipid profile.

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Drug Interactions

Reduced contraceptive efficacy w/ hepatic enzyme-inducers eg, carbamazepine, griseofulvin, modafinil, nelfinavir, nevirapine, oxcarbazepine, phenytoin, phenobarb, primidone, ritonavir, St. John's wort, topiramate, rifabutin, rifampicin & rufinamide. May result to contraceptive failure w/ aprepitant & bosentan. May increase incidence of side effects w/ amprenavir, sitaxentan, atorvastatin & tacrolimus. May enhance or reduce anticoagulant effect of coumarins & increase clearance of analgesics (eg, paracetamol & morphine). May antagonize hypoglycemic effect of antidiabetics & anticoagulant effect of phenindione. May increase plasma conc of ciclosporin, selegiline & tizanidine. May reduce plasma conc of lamotrigine.

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Storage

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Description

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Action

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MIMS Class

Oral Contraceptives

ATC Classification

G03DC03 - lynestrenol ; Belongs to the class of estren derivative progestogens used in progestogenic hormone preparations.

Regulatory Classification

Presentation/Packing

Form

Daphne tab 500 mcg

Packing/Price

28's

Daphne

lynestrenol

Manufacturer:

DKT

Distributor:

DKT