Coxicare Dosage/Direction for Use

In osteoarthritis, etoricoxib is given orally in a usual dose of 30 mg once daily, increased to 60 mg once daily if necessary. The recommended dose in rheumatoid arthritis is 90 mg once daily; higher doses of 120 mg once daily are used in gouty arthritis although such doses should only be used for the acute symptomatic period and for a maximum of 8 days.
Administration in hepatic impairment: The maximum oral dose of etoricoxib in patients with mild hepatic impairment (Child-Pugh score of 5 to 6), regardless of indication, is 60 mg once daily; those with moderate impairment (Child-Pugh 7 to 9) should be given a maximum of 60 mg every other day or 30 mg once daily. Etoricoxib should not be given to patients with severe hepatic impairment (Child-Pugh 10 or more).
Musculoskeletal and joint disorders: The selective cyclo-oxygenase-2 (COX-2) inhibitor etoricoxib is used in the treatment of the musculoskeletal disorders osteoarthritis and rheumatoid arthritis. It is recommended that the use of selective COX-2 inhibitors is limited to those patients considered to be at high risk of developing serious gastrointestinal problems if given a non-selective NSAID.