Prophylaxis & treatment of venous thrombosis, atrial fibrillation w/ embolization, pulmonary embolism, adjunct in prophylaxis of systemic embolism after MI & in treatment of coronary occlusion.
View Coumadin overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Hemorrhagic tendency or blood dyscrasias. Recent or contemplated surgery of CNS, eye or traumatic surgery resulting in large open surfaces. Bleeding tendencies associated w/ active ulceration or overt bleeding of GI, genitourinary or resp tracts; cerebrovascular hemorrhage; cerebral aneurysms, dissecting aorta; pericarditis & pericardial effusions; bacterial endocarditis. Threatened abortion, eclampsia & preeclampsia. Unsupervised patients w/ senility, alcoholism, psychosis or lack of patient cooperation. Spinal puncture. Major regional, lumbar block anesth, malignant HTN. Pregnancy.
Any predisposing condition where added risk of hemorrhage, necrosis &/or gangrene is present. Determine prothrombin time/INR or other suitable coagulation tests periodically. Known or suspected hereditary, familial or clinical deficiency in protein has been associated w/ an increased risk of developing necrosis during warfarin administration. Discontinue use when systemic cholesterol microembolization including "purple toes syndrome" occurs. Patients w/ heparin-induced thrombocytopenia & DVT. Severe elevation in aPTT (>50 sec). Severe to moderate HTN, hepatic or renal insufficiency. Infectious diseases or disturbances of intestinal flora. Surgery or trauma. Indwelling catheters. Polycythemia vera, vasculitis & severe diabetes. CHF. Concomitant use w/ streptokinase or urokinase. Women of childbearing potential. Lactation. Childn <18 yr. Elderly ≥60 yr.
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