Cosopt/Cosopt-S Description

Cosopt: Each milliliter of DORZOLAMIDE HCl + TIMOLOL MALEATE (COSOPT) contains 20.00 mg dorzolamide (22.26 mg dorzolamide hydrochloride) and 5.00 mg timolol (6.83 mg of timolol maleate) as the active ingredients.
Sterile, isotonic, buffered, slightly viscous, aqueous solution.
DORZOLAMIDE HCl + TIMOLOL MALEATE (COSOPT) Ophthalmic Solution is the first combination of a topical carbonic anhydrase inhibitor and a topical beta-adrenergic receptor blocking agent.
DORZOLAMIDE HCl + TIMOLOL MALEATE (COSOPT) contains dorzolamide hydrochloride and timolol maleate.
Dorzolamide Hydrochloride: Dorzolamide hydrochloride is described chemically as: (4S-trans)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno [2,3-b]thiopyran-2- sulfonamide 7,7-dioxide monohydrochloride.
Its empirical formula is C₁₀H₁₆N₂O₄S₃ HCl.
Dorzolamide hydrochloride has a molecular weight of 360.91. It is a white to off-white, free flowing crystalline powder, which is soluble in water and slightly soluble in methanol and ethanol.
Timolol Maleate: Timolol maleate is described chemically as: (S)-1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2- propanol,(Z)-2-butenedioate (1:1) (salt). Timolol maleate possesses an asymmetric carbon atom in the structure and is provided as the levo isomer.
The empirical formula is C₁₃H₂₄N₄O₃SC₄H₄O₄.
Timolol maleate has a molecular weight of 432.50. It is a white, odorless, crystalline powder which is soluble in water, methanol, and alcohol.
Cosopt-S: Dorzolamide HCl/Timolol Maleate (Cosopt-S) is a clear, colourless to nearly colourless, slightly viscous ophthalmic solution containing 22.26mg of Dorzolamide Hydrochloride corresponding to 20mg Dorzolamide and 6.83mg of Timolol Maleate corresponding to 5mg Timolol in each mL, or 4mg of Dorzolamide and 1mg of Timolol in each single-dose container (0.2 mL). It also contains hydroxyethylcellulose, mannitol, sodium citrate, sodium hydroxide (for pH adjustment) and water for injection.