Colhetz

Colhetz

colistimethate sodium

Manufacturer:

Aspiro Pharma

Distributor:

Camber
Concise Prescribing Info
Contents
Colistimethate Na (equiv to 150 mg colistin base)
Indications/Uses
Acute or chronic infections due to sensitive strains of certain gram -ve bacilli eg, Enterobacter aerogenes, E. coli, Klebsiella pneumoniae & Pseudomonas aeruginosa.
Dosage/Direction for Use
IM/IV Adult & ped patient w/ normal renal function (CrCl ≥80 mL/min) 2.5-5 mg/kg daily in 2-4 divided doses, depending on the severity of infection. Max: 5 mg/kg daily. Adult w/ mild renal impairment (CrCl 50-79 mL/min) 2.5-3.8 mg/kg divided into 2 doses daily; moderate renal impairment (CrCl 30-49 mL/min) 2.5 mg/kg once daily or divided into 2 doses daily; severe renal impairment (CrCl 10-29 mL/min) 1.5 mg/kg every 36 hr.
Contraindications
Special Precautions
Transient neurological disturbances may occur. Nephrotoxicity. Discontinue if C. difficile-associated diarrhea is suspected or confirmed. Risk of the development of drug-resistant bacteria in the absence of a proven or strongly suspected bacterial infection. Concomitant use w/ other antibiotics & curariform drugs. Impaired renal function. May affect ability to drive vehicles or use hazardous machinery. Pregnancy & lactation. Elderly. Childn.
Adverse Reactions
GI upset; tingling of extremities & tongue, slurred speech, dizziness, vertigo, paresthesia; generalized itching, urticaria, rash; fever; increased BUN, elevated & decreased CrCl; resp distress, apnea; nephrotoxicity, decreased urine output.
Drug Interactions
Interfered nerve transmission at the neuromuscular junction w/ aminoglycosides & polymyxin. Potentiated neuromuscular blocking effect w/ curariform muscle relaxants (eg, tubocurarine), ether, succinylcholine, gallamine, decamethonium, & Na citrate. May enhance nephrotoxicity w/ Na cephalothin.
MIMS Class
Other Antibiotics
ATC Classification
J01XB01 - colistin ; Belongs to the class of polymyxins. Used in the systemic treatment of infections.
Presentation/Packing
Form
Colhetz lyo powd for inj 384.61 mg
Packing/Price
10 mL x 10 × 1's
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in