Hypersensitivity to penicillins or cephalosporins. Not to be given to patients w/ a history of penicillin allergy. Incompatible w/ aminoglycosides, tetracyclines, erythromycin & polymyxin B. Not to be administered to neonates born of mothers who are hypersensitive to penicillin.
Generalized sensitivity reaction can develop w/in few hr or wk of commencing treatment. Supra-infection w/ C. albicans, other fungi or organisms may occur. Risk of neurotoxicity & CHF in administration of high doses in patients w/ renal impairment. Electrolyte balance disturbance may occur following administration of large doses. Increased liver enzymes. Monitor renal & haematological systems during prolonged & high-dose therapy. Patients w/ syphilis may exhibit Jarisch-Herxheimer reaction. Use a skin test for sensitivity to determine patients who are most likely to develop allergic reactions to penicillin.
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