Adult 625 mg tab every 12 hr or 375 mg tab every 8 hr. More severe infections & resp tract infections 1,000 mg tab every 12 hr or 625 mg tab every 8 hr. Severely impaired patient w/ GFR 10-30 mL/min 625 mg or 375 mg every 12 hr, <10 mL/min 625 mg or 375 mg every 24 hr. Ped patientweighing ≥40 kg Adult dose.
May be taken with or without food: Best taken at the start of meals for better absorption & to reduce GI discomfort.
Contraindications
Hypersensitivity to amoxicillin, clavulanic acid, or β-lactams (eg, penicillins or cephalosporins). Patients w/ previous history of Co-Amoxiclav associated jaundice/hepatic dysfunction.
Should not be used w/ drugs that delay peristalsis (eg, opiates & diphenoxylate w/ atropine). Fluids, electrolytes & protein replacement therapy should be provided when indicated. Patients w/ evidence of hepatic dysfunction. Avoid during pregnancy (especially 1st trimester). Lactation.
May prolong or worsen the condition w/ drugs that delay peristalsis (eg, opiates & diphenoxylate w/ atropine). Transient decrease in plasma conc of total conjugated estriol, cestadiol in pregnant women. Amoxicillin: Decreased renal tubular secretion w/ probenecid. Disulfiram (antabuse) like reaction w/ alcohol.
J01CR02 - amoxicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
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