Severe liver impairment. Immunosuppressed patients should avoid exposure to measles or chickenpox especially in childn. Vaccination. Latent TB. Hypothyroidism, cirrhosis. Ocular herpes simplex. Psychotic disorders. GI ulceration. Pregnancy & lactation.
Increase plasma conc of loratadine w/ ketoconazole, erythromycin or cimetidine. Enhance metabolism of betamethasone w/ phenobarb, phenytoin, rifampin or ephedrine. Enhance hypokalemia w/ K-depleting diuretics & effect w/ estrogen. Concurrent use of corticosteroids w/ cardiac glycosides may enhance possibility of arrhythmias or digitalis toxicity associated w/ hypokalemia; enhance K-depletion caused by amphotericin B; may increase or decrease anticoagulant effects w/ coumarin. Increased occurrence or severity of GI ulceration w/ NSAIDs or alcohol. Corticosteroid may decrease blood salicylate conc. Concomitant glucocorticosteroid therapy may inhibit response to somatotropin. Antidiabetic drugs.
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