Adult 1 g IV/IM 8-12 hrly. Uncomplicated UTI 250 mg IV/IM 12 hrly. Bone & joint infections 2 g IV 12 hrly. Complicated UTI 500 mg IV/IM 8-12 hrly. Uncomplicated pneumonia, mild skin & skin structure infections 500 mg-1 g IV/IM 8 hrly. Serious gynecologic & intra-abdominal infections 2 g IV 8 hrly. Meningitis 2 g IV 8 hrly. Very severe life-threatening infections especially in immunocompromised patients 2 g IV 8 hrly. Lung infections caused by Pseudomonas spp in patients w/ cystic fibrosis w/ normal renal function 30-50 mg/kg IV 8 hrly. Max: 6 g/day. Infant & childn 1 mth-12 yr 30-50 mg/kg IV 8 hrly. Max: 6 g/day. Neonate 0-4 wk 30 mg/kg IV 12 hrly.
History of hypersensitivity reactions to cephalosporins & penicillin. Reduce dose in patients w/ renal insufficiency, history of GI disease (colitis). C. difficile-associated diarrhea. Avoid prolonged use. Resistance leading to clinical failure. Monitor prothrombin time in patients w/ renal or hepatic impairment, poor nutritional state & those receiving antimicrobial therapy. History of GI disease particularly colitis. Distal necrosis after intra-arterial administration. Pregnancy & lactation. Elderly.
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