Dose may be given by deep IM inj, slow IV inj over 3-5 min, or by continuous IV infusion.
Adult Usual dose: 1-2 g every 8 hr or every 4 or 6 hr.
Severe infections Up to 12 g daily.
Uncomplicated UTI 1 g IM bid.
Uncomplicated gonorrhoea 2 g IM as a single dose w/ probenecid 1 g PO.
Surgical infection prophylaxis 2 g IM/IV 30-60 min prior to the procedure & then every 6 hr not usually for >24 hr.
Caesarean section 2 g IV as a single dose given as soon as umbilical cord is clamped. A 3-dose regimen w/ further 2-g doses 4 & 8 hr after initial dose may be used if necessary.
Childn & older infant 20-40 mg/kg every 6-8 hr.
Surgical infection prophylaxis 30-40 mg/kg 30-60 min prior to the procedure & then every 6 hr not usually for >24 hr.
Neonate 1-4 wk 20-40 mg/kg every 8 hr,
up to 1 wk 20-40 mg/kg every 12 hr.
Surgical infection prophylaxis 30-40 mg/kg every 8-12 hr.
Renal impairment Loading dose: Initially 1-2 g. Maintenance dose:
CrCl 30-50 mL/min 1-2 g every 8-12 hr,
10-29 mL/min 1-2 g every 12-24 hr,
5-9 mL/min 500 mg-1 g every 12-24 hr,
<5 mL/min 500 mg-1 g every 24-48 hr.
Patient undergoing hemodialysis Repeat loading dose after each dialysis session.
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