Deep IM inj or slow IV inj over 3-5 min or by infusion over 20-60 min.
Adult 2-6 g daily in 2-4 divided doses.
Severe infections Up to 12 g daily by IV in up to 6 divided doses.
Pseudomonal infections >6 g daily.
Gonorrhea 500 mg or 1 g as single dose.
Surgical infection prophylaxis 1 g for 30-90 min before surgery.
Caesarean section 1 g IV given after the umbilical cord is clamped, then 2 further doses IM/IV 6 & 12 hr later.
Childn 100-150 mg/kg daily in 2-4 divided doses.
Severe infections 200 mg/kg daily.
Neonate 50 mg/kg daily in 2-4 divided doses.
Severe infections 150-200 mg/kg daily.
Severe renal impairment Initial loading dose of 1 g then halving the dose while maintaining usual frequency of dosing.
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