HTN including HTN crisis. Prophylaxis of migraine or recurrent vascular headaches. Menopausal flushing. Cancer pain. Opioid w/drawal, phaechromocytoma. Glaucoma. Tourette's syndrome & other disorders.
Hypertensive crisis 150-300 mcg over 10-15 min slow IV inj. Up to 750 μg may be given IV over 24 hr. Severe HTN Initially 100-200 μg followed by 50-100 μg every hr or max: 500-800 μg. Prophylaxis of migraine or recurrent vascular headaches, menopausal flushing 50 μg by mouth bid, increased 2 wk after remission to 75 μg bid. Severe cancer pain Initially 30 μg/dose by continuous epidural infusion.
Enhanced effects w/ diuretics, other hypertensives & other drugs that cause hypotension. May exacerbate rebound HTN w/ β-blockers; may antagonize hypotensive effect w/ TCA. May enhanced effect w/ CNS depressants.
C02AC01 - clonidine ; Belongs to the class of imidazoline receptor agonists, centrally-acting antiadrenergic agents. Used in the treatment of hypertension.
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