Slow IV infusion over approx 1 hr.
Adult Loading dose: 70 mg on day 1, followed by 50 mg daily thereafter;
>80 kg 70 mg daily, after initial 70 mg loading dose.
Ped patient (12 mth-17 yr) 70 mg/m
2 as single loading dose (not to exceed an actual dose of 70 mg) on day 1. Followed by 50 mg/m
2 daily thereafter. Max: 70 mg daily. May be increased to 70 mg/m
2 daily if 50 mg/m
2 daily dose is well tolerated but does not provide adequate clinical response. Max: 70 mg daily.
Moderate hepatic impairment 35 mg daily. Initial 70 mg loading dose should be administered on day 1.
Co-administration w/ inducers of metabolic enzymes Adult Increase daily dose to 70 mg, following 70 mg loading dose.
Ped patient 70 mg/m
2 daily. Max: 70 mg daily.
Invasive candidiasis Continue for at least 14 days after last +ve culture.
Invasive aspergillosis Continue therapy for at least 7 days after resolution of symptoms.
Empirical therapy Continue until up to 72 hr after resolution of neutropenia (ANC=500). Patients found to have fungal infection should be treated for min of 14 days & continue treatment for at least 7 days after both neutropenia & clinical symptoms are resolved.
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