Management of HTN & angina pectoris. Adjunct to standard therapy in symptomatic heart failure. Reduce mortality in patients w/ left ventricular dysfunction following MI.
25 mg daily. Initially 12.5 mg daily for the 1st 2 days. Thereafter, continue w/ 25 mg daily. May be increased to 25 mg bid after at least 14 days. Max: Single dose of 25 mg daily or a total daily dose of 50 mg.
May mask early warning signs of hypoglycemia w/ insulin or oral antidiabetic drugs. Irregular heart rhythm or increased BP w/ Ca channel blockers eg, diltiazem or verapamil. Steep decline in BP &/or heart rate w/ reserpine, MAOIs & clonidine. Increased digoxin & cyclosporin blood levels. Decreased blood levels w/ rifampin. Increased blood levels & risk of side effects w/ quinidine, fluoxetine, paroxetine or propafenone.
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