Previously untreated adult patient w/ normal renal function 400 mg/m2 as short-term IV infusion (15-60 min). Therapy should not be repeated until 4 wk after previous carboplatin course.
Monitor hematologic & renal function tests. Perform blood counts prior to therapy & at wkly intervals thereafter. Neurological evaluation & assessment of hearing should also be performed on a regular basis. Long-term therapy. Abnormal kidney function or concomitant therapy w/ drugs w/ nephrotoxic potential. Frequent monitoring of peripheral blood counts throughout & following therapy. Manifestation or exacerbation of infections & bleeding tendency. Women of childbearing potential. Childn. Elderly.
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