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Pregnancy: The safe use of Carboplatin during pregnancy has not been established: Studies in animals have shown reproductive toxicity. Carboplatin has been shown to be an embryo toxin and teratogen in rats and mutagenic in vivo and in vitro. Carboplatin should not be used during pregnancy unless clearly indicated. If Carboplatin is used during pregnancy the patient should be apprised of the potential hazard to the fetus.
Fertility: Women of childbearing potential should be advised to avoid becoming pregnant by using effective contraception during treatment and up to 6 months after therapy. For women who are pregnant or become pregnant during therapy, genetic counseling should be provided.
Carboplatin is genotoxic. Men being treated with carboplatin are advised not to father a child during and up to 6 months after treatment and to seek advice on conservation of sperm prior to treatment because of the possibility of irreversible infertility due to therapy with carboplatin.
Lactation: It is not known whether Carboplatin is excreted in human milk. Because of the possibility of harmful effects in suckling infants, breast-feeding must be discontinued if the mother is treated with Carboplatin.
