Replacement therapy in adrenocortical insufficiency in combination w/ more potent mineralocorticoid. May also be used in other conditions for which corticosteroid therapy is indicated.
Heart failure, recent MI, HTN, DM, epilepsy, glaucoma, hypothyroidism, hepatic & renal failure, osteoporosis, peptic ulceration, psychoses or severe affective disorders & renal impairment. Do not give live vaccines for at least 3 mth after corticosteroid therapy. Monitor fluid intake & output. Avoid rapid IV inj in high doses. Childn. Elderly.
Na & water retention w/ edema & HTN; hypokalemic alkalosis, increased appetite, excessive metabolic effects resulting in Ca & P mobilization w/ osteoporosis & spontaneous fractures, nitrogen depletion, hyperglycemia, delay wound healing; fetal/neonatal adrenal suppression in high dosage during pregnancy.
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