Moderate to severe hepatic impairment; preexisting diabetes. Periodic liver function test & monitor blood glucose. Co-administration w/ drugs metabolized predominantly by CYP3A4. Patients w/ a history of/or risk factors for QT prolongation. Patients receiving medicinal products that might prolong the QT interval. May impair ability to drive or operate machinery.
Midazolam, terfenadine, astemizole, cisapride, cyclosporin, Ca-channel blockers, drugs which may inhibit drug oxidation eg, cimetidine & ketoconazole; coumarin anticoagulant, warfarin, medicinal products known to prolong the QT interval or medicinal products able to induce Torsade de pointes eg, class IA (eg, quinidine, disopyramide) or class III (eg, amiodarone, sotalol, dofetilide, ibutilide), antiarrhythmic medicinal products, methadone, moxifloxacin, antipsychotics.
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