Adult & childn >12 yr 400 mg as single dose or in 2 divided doses. Childn 8 mg/kg/day. Renal impairment CrCl 21-60 mL/min & on hemodialysis 75% of the standard dosage at the standard dosing interval. Patient on continuous ambulatory peritoneal dialysis ½ of the standard dosage at the standard dosing interval.
Hypersensitivity to penicillin. May cause severe antibiotic-associated diarrhea including pseudomembranous colitis. Patients w/ markedly impaired renal function. Patients w/ history of GI disease particularly colitis. False +ve reaction for ketones in the urine w/ tests using nitroprusside; glucose in the urine w/ Benedict's or Fehling's soln or w/ Cu sulfate test caps; Coombs' test. Pregnancy & lactation. Childn <6 mth.
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