HTN Initially 12.5 mg once daily, increased to 25 mg once daily after 2 days. Alternatively, initial dose of 6.25 mg bid, increased to 12.5 mg bid after 1-2 wk. May be further increased to 50 mg once daily or in divided doses at intervals of at least 2 wk. Elderly 12.5 mg once daily. Angina pectoris Initially 12.5 mg bid, increased to 25 mg bid after 2 days. Heart failure Initially 3.125 mg bid. If tolerated, double the dose to 6.25 mg bid after 2 wk & then increase gradually at intervals of not <2 wk. Patient w/ mild to moderate heart failure >85 kg 50 mg bid, severe heart failure or <85 kg Max: 25 mg bid.
View Betacard overdosage for action to be taken in the event of an overdose.
Administration
Should be taken with food.
Contraindications
Hypersensitivity. Unstable/decompensated heart failure; clinically manifest liver dysfunction; 2nd- or 3rd-degree AV block (unless a permanent pacemaker is in place); severe bradycardia (<50 bpm); sick sinus syndrome (including SA block); severe hypotension (systolic <85 mmHg); cardiogenic shock; history of bronchospasm or asthma; metabolic acidosis; severe peripheral arterial disease.
Not to be given to patients w/ bronchospasm or asthma or those w/ history of obstructive airways disease. 1st-degree AV block. Pheochromocytoma w/o concomitant α-adrenoceptor blocking therapy. Abrupt w/drawal may exacerbate angina. Reduced peripheral circulation can produce coldness of the extremities & may exacerbate peripheral vascular disease (eg, Raynaud's syndrome). Pregnancy. Not recommended during lactation.
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