In lower resp tract infections including bronchitis & pneumonia; resp tract infections (including otitis media), skin & soft-tissue infections & uncomplicated genital infections. Prophylaxis & as a component regimen in the treatment of M. avium complex (MAC). Prophylaxis of endocarditis in at-risks patients unable to take penicillin. Management of trachoma & typhoid.
Adult Usual dose: 500 mg daily as single dose for 3 days. Initially, 500 mg followed by 250 mg daily for 4 days. Uncomplicated genital infections due to C. trachomatis 1 g as a single dose. Uncomplicated gonorrhea 2 g as a single dose. Prophylaxis of disseminated MAC infections 1.2 g once wkly. Childn >2 yr 12 mg/kg once daily for 5 days, >6 mth 10 mg/kg once on the 1st day then 5 mg/kg for 4 days.
Reduced rate of absorption w/ antacids containing Al or Mg salts. Possibility of ergotism w/ ergot derivatives. Impaired metabolism of digoxin (in the gut). Increased rifabutin toxicity.
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