Aviar Drug Interactions

Although no formal drug interaction studies have been performed, Tiotropium bromide has been used concomitantly with other drugs, commonly used in the treatment of COPD, including sympathomimetic bronchodilators, methylxanthines, oral and inhaled steroids, antihistamines, mucolytics, leucotriene modifiers, cromones, and anti-IgE treatment without adverse drug reactions or clinical evidence of drug interactions.
Common concomitant medications (LABA, ICS and their combinations) used by patients with COPD were not found to alter the exposure to Tiotropium.
Limited information about co-administration of other anticholinergic drugs with Tiotropium bromide is available from two clinical trials: Acute single dose administration of ipratropium bromide with chronically administered Tiotropium bromide in COPD patients (n=64) and healthy volunteers (n=35) was not associated with an increase in adverse events, changes in vital signs or electrocardiographic findings. However, chronic co-administration of other anticholinergic drugs with Tiotropium bromide has not been studied and is, therefore not recommended.