Reduces LDL-cholesterol, apolipoprotein B & triglycerides; increases HDL-cholesterol in the treatment of hyperlipidemias. Adjunct therapy in patients w/ homozygous familial hypercholesterolemia who have some LDL-receptor function. Primary prophylaxis of CV events in patients w/ multiple risk factors.
Dose range: 10-80 mg once daily. Doses may be given any time of the day. Dosage should be individualized according to baseline LDL-cholesterol levels, goal of therapy & patient response. Primary hypercholesterolemia & combined hyperlipidemia 10 mg once daily. Homozygous familial hypercholesterolemia 10-80 mg daily.
Perform liver function tests & monitor for creatine phosphokinase & transaminase elevations. Avoid alcohol consumption. Temporarily discontinue therapy in patients w/ an acute, serious condition suggestive of a myopathy or renal failure secondary to rhabdomyolysis.
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